Figure 3. Higher percentage of CD3⁺CD8⁺TCRγδ IELs express NKG2A in patients on GFD.

(A) Representative flow cytometry histograms showing percentage of CD3-gated CD8⁺TCRγδ^–, CD8⁺TCRγδ⁺, and CD8^–TCRγδ⁺ IELs (sorted from the jejunal biopsies of a GFD patient) expressing surface NKG2A. (B) Box-and-whisker plots comparing percentage of CD3⁺TCRαβ⁺NKG2A⁺ IELs with percentage of CD3⁺TCRγδ⁺NKG2A⁺ IELs. (C) Box and Whisker plots comparing frequencies of CD3⁺CD8⁺TCRγδ⁺ IELs and CD3⁺CD8^–TCRγδ⁺ IELs expressing NKG2A, from ACD patients (n = 15), GFD patients (n = 23), and controls (n = 10) (P values determined by Mann-Whitney U test).