Table 2.
Extrinsic pathway proteins, abbreviations, and alternate nomenclature.
| Abbreviation | Protein Name | Select Alternate Nomenclature |
|---|---|---|
| TNF-α | Tumor necrosis factor alpha | TNF ligand, TNFA, cachectin |
| TNFR1 | Tumor necrosis factor receptor 1 | TNF receptor, TNFRSF1A, p55 TNFR, CD120a |
| FasL | Fatty acid synthetase ligand | Fas ligand, TNFSF6, Apo1, apoptosis antigen ligand 1, CD95L, CD178, APT1LG1 |
| FasR | Fatty acid synthetase receptor | Fas receptor, TNFRSF6, APT1, CD95 |
| Apo3L | Apo3 ligand | TNFSF12, Apo3 ligand, TWEAK, DR3LG |
| DR3 | Death receptor 3 | TNFRSF12, Apo3, WSL-1, TRAMP, LARD, DDR3 |
| Apo2L | Apo2 ligand | TNFSF10, TRAIL, TNF-related apoptosis inducing ligand |
| DR4 | Death receptor 4 | TNFRSF10A, TRAILR1, APO2 |
| DR5 | Death receptor 5 | TNFRS10B, TRAIL-R2, TRICK2, KILLER, ZTNFR9 |
| FADD | Fas-associated death domain | MORT1 |
| TRADD | TNF receptor-associated death domain | TNFRSF1A associated via death domain |
| RIP | Receptor-interacting protein | RIPK1 |
| DED | Death effector domain | Apoptosis antagonizing transcription factor, CHE1 |
| caspase-8 | Cysteinyl aspartic acid-protease 8 | FLICE, FADD-like Ice, Mach-1, Mch5 |
| c-FLIP | FLICE-inhibitory protein | Casper, I-FLICE, FLAME-1, CASH, CLARP, MRIT |
References:
1
Human Protein Reference Database 〈http://www.hprd.org/〉.
2
ExPASy Proteomics Server 〈http://ca.expasy.org/〉.