Table 3.
Intrinsic pathway proteins, abbreviations, and alternate nomenclature.
| Abbreviation | Protein Name | Select Alternate Nomenclature |
|---|---|---|
| Smac/DIABLO | Second mitochondrial activator of caspases/direct IAP binding protein with low PI | None |
| HtrA2/Omi | High-temperature requirement | Omi stress regulated endoprotease, serine protease Omi protein A2 |
| IAP | Inhibitor of Apoptosis Proteins | XIAP, API3, ILP, HILP, HIAP2, cIAP1, API1, MIHB, NFR2-TRAF signaling complex protein |
| Apaf-1 | Apoptotic protease activating factor | APAF1 |
| Caspase-9 | Cysteinyl aspartic acid-protease-9 | ICE-LAP6, Mch6, Apaf-3 |
| AIF | Apoptosis Inducing Factor | Programmed cell death protein 8, mitochondrial |
| CAD | Caspase-Activated DNAse | CAD/CPAN/DFF40 |
| Bcl-2 | B-cell lymphoma protein 2 | Apoptosis regulator Bcl-2 |
| Bcl-x | BCL2 like 1 | BCL2 related protein |
| Bcl-XL | BCL2 related protein, long isoform | BCL2L protein, long form of Bcl-x |
| Bcl-XS | BCL2 related protein, short isoform | |
| Bcl-w | BCL2 like 2 protein | Apoptosis regulator BclW |
| BAG | BCL2 associated athanogene | BAG family molecular chaperone regulator |
| Bcl-10 | B-cell lymphoma protein 10 | mE10, CARMEN, CLAP, CIPER |
| BAX | BCL2 associated X protein | Apoptosis regulator BAX |
| BAK | BCL2 antagonist killer 1 | BCL2L7, cell death inhibitor 1 |
| BID | BH3 interacting domain death agonist | p22 BID |
| BAD | BCL2 antagonist of cell death | BCL2 binding protein, BCL2L8, BCL2 binding component 6, BBC6, Bcl-XL/Bcl-2 associated death promoter |
| BIM | BCL2 interacting protein BIM | BCL2 like 11 |
| BIK | BCL2 interacting killer | NBK, BP4, BIP1, apoptosis inducing NBK |
| Blk | Bik-like killer protein | B lymphoid tyrosine kinase, p55-BLK, MGC10442 |
| Puma | BCL2 binding component 3 | JFY1, PUMA/JFY1, p53 up-regulated modulator of apoptosis |
| Noxa | Phorbol-12-myristate-13-acetate-induced protein 1 | PMA induced protein 1, APR |
| 14-3-3 | Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein | 14-3-3 eta, theta, zeta, beta, epsilon, sigma, gamma |
| Aven | Cell death regulator Aven | None |
| Myc | Oncogene Myc | c-myc, Myc proto-oncogene protein |
References
1
Human Protein Reference Database 〈http://www.hprd.org/〉.
2
ExPASy Proteomics Server 〈http://ca.expasy.org/〉.