Table 8.

Effect of developmental exposure to PBDEs on plasma T₄ levels

PBDE	Species	Treatment	Effect	Reference
BDE-47	Wistar rats	0.14, 0.7 mg/kg, oral, in po, GD6	Decrease in females on PND14, not on PND1, 22. Decrease in dams on PND1, not on PND22	Talsness et al. 2004; Kuriyama et al. 2004b
BDE-99	CD-1 Swiss mice	18 mg/kg, oral, in co, GD6- PND21, by self administration	N.S. decrease on PND22	Branchi et al. 2005
BDE-99	NMRI mice	80 umol/kg, oral, in co, every 3 days, GD4- PND17	No effect	Skarman et al. 2005
BDE-209	C57BL6/J mice	6, 20 mg/kg, oral, in el/po, PND2–15	Decrease in males on PND21 (20 mg/kg)	Rice et al. 2007
DE-71	Long Evans rat	0.3, 1, 3, 10, 30, 100, 300 mg/kg, oral in co, PND28–31 (female only)	Decrease on PND32. No effects on T3	Zhou et al. 2001
DE-71	Long Evans rats	1, 10, 30 mg/kg, oral, in co, GD6- PND21	Decrease on GD20 (fetus), PND4, 22 (10,30 mg/kg) Recovery by PND36	Zhou et al. 2002
DE-71	Sprague Dawley rats	18 mg/kg, oral in co, GD6- PND18	Decrease on PND18. Recovery by PND31	Ellis-Hutchings et al. 2006
DE-71	Rats	1, 5, 30, 100 mg/kg, oral, in co, GD6- PND21	Decrease on PND5, 14 (5–100 mg/kg)	Taylor et al. 2003 (abstract)
DE-71	Ranch mink (Mustela vison)	1, 5, 10 ppm in feed for 11 wks from weaning	Decrease at 5, 10 ppm. Decrease of T3	Martin et al. 2004
Bromkal- 705DE	NMRI mice	80 umol/kg, oral, in co, every 3 days GD4-PND17	Decrease on PND11. Recovery by PND18	Skarman et al. 2005
DE-79	Long Evans rats	0.3, 1, 3, 10, 30, 60, 100 mg/kg, oral in co, PND28–31 (female only)	Decrease on PND32. No effect on T3	Zhou et al. 2001
DE-83R	Long Evans rats	0.3, 1, 3, 10, 30, 60, 100 mg/kg, oral in co, PND28–31 (female only)	No effect	Zhou et al. 2001

Abbreviations: co, corn oil; el/po, egg lecithin/peanut oil; N.S., not significant.

DE-83R is a >98% decaPBDE mixture.