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. 2006 Jan 23;203(1):227–238. doi: 10.1084/jem.20051645

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Copyright © 2006, The Rockefeller University Press

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Figure 4. — Enforced expression of huFlt3 permits myelomonocytic development from huFlt3⁺-MEPs but not megakaryocyte/erythrocyte development from huFlt3⁺-GMPs. (A) Bar graph shows myeloid colony–forming activity in normal and retrovirus-transduced myeloid progenitors (MEPs, GMPs, and CMPs). CFU-GEMM, CFU-granulocyte/erythroid/macrophage/megakaryocyte; CFU-MegE, CFU-megakaryocyte/erythroid; CFU-Meg, CFU-megakaryocyte; BFU-E, burst-forming units/erythroid; CFU-GM, CFU-granulocyte/macrophage; CFU-M, CFU-macrophage; CFU-G, CFU-granulocyte. Results are from one representative experiment out of three. 200 GFP⁺ cells were plated each. (B) Enforced expression of huFlt3 in MEPs is sufficient to rescue IPC, DC, and myelomonocytic cell development in vivo. Contour plots show GFP expression in day 7 spleen progeny of GFP ⁺-MEPs, huFlt3 ⁺-MEPs, and GFP ⁺-CMPs. Numbers at gates represent percentages of total plotted cells. Results are from one representative experiment out of four.