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. 2006 Jan 23;203(1):131–140. doi: 10.1084/jem.20051794

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Copyright © 2006, The Rockefeller University Press

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Figure 4. — Knockout of Mkp-1 shifts the pattern of cytokine expression in splenocytes and dendritic cells. (A) Cytokine expression in LPS-stimulated splenocytes. Splenocytes isolated from Mkp-1 ^+/+ and Mkp-1 ^−/− mice were stimulated with 100 ng/ml LPS for the indicated times, and cytokine concentrations in the medium were assayed by ELISA. IFN-γ levels were measured 24 h after LPS treatment. Data are presented as the mean ± SEM (n = 3–9 for each group). *, Mkp-1 ^−/− different from Mkp-1 ^+/+, P < 0.05. (B) Cytokine production by bone marrow–derived dendritic cells from both Mkp-1 ^+/+ and Mkp-1 ^−/− mice. Cells were stimulated with 1 μg/ml LPS for 24 h. Data are presented as mean ± SEM (n = 3 in each group). *, Mkp-1 ^−/− different from Mkp-1 ^+/+ , P < 0.05; #, Mkp-1 ^−/− different from Mkp-1 ^+/+, P < 0.005.