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. 2006 Jan 23;203(1):131–140. doi: 10.1084/jem.20051794

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Copyright © 2006, The Rockefeller University Press

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Figure 5. — Deficiency in Mkp-1 enhances LPS-triggered production of TNF-α, IL-6, and IL-10 in vivo. (A) Both Mkp-1^+/+ and Mkp-1 ^−/− mice were injected i.p. with either vehicle (PBS) or LPS at indicated doses. Mice were killed 90 min later and plasma cytokine concentrations were measured by ELISA. Data are presented as mean ± SEM (n = 6 in each group). Two-way ANOVA demonstrates a significant effect of both genotype (P < 0.001) and LPS dose (P = 0.005) on TNF-α and IL-6 concentrations. (B) Mice were injected i.p. with LPS (1.5 mg/kg body weight) and killed at the indicated times. Serum cytokines were measured using ELISA. Data are presented as mean ± SEM (n = 10). Two-way ANOVA demonstrates a significant effect of both genotype and time after LPS challenge on TNF-α, IL-6, and IL-10 concentrations (P < 0.001).