Figure 7.

LPS causes renal, heptic, and pulmonary damages in Mkp-1^−/− mice. Mice were challenged with LPS (1.5 mg/kg body weight) and killed 24 h later. Plasma BUN and ALT activity were measured. Lungs were perfused and fixed with formalin, and 4-μm sections were stained with hematoxylin and eosin. (A) BUN and ALT activities in vehicle- and LPS-challenged mice. Data are presented as mean ± SEM of 8–13 independent experiments. *, P < 0.001, one-way ANOVA comparing Mkp-1 ^+/+ with Mkp-1 ^−/− groups. (B) Representative images of lung sections from LPS-challenged wild-type and Mkp-1 ^−/− mice.