Table II.
Association of the CCR5Δ32 allele with symptomatic WNV infection in Arizona and Colorado
|
CCR5Δ32 Genotype, n (%)
|
||||||
|---|---|---|---|---|---|---|
| All racial groups
|
Self-reporting Caucasians
|
|||||
| Cohort | +/+ | +/Δ32 | Δ32/Δ32 | +/+ | +/Δ32 | Δ32/Δ32 |
| Arizona WNV+ | 205 (83.0) | 31 (12.6) | 11 (4.5) | 115 (80.4) | 22 (15.4) | 6 (4.2) |
| Colorado WNV+ | 111 (75.0) | 31 (20.9) | 6 (4.1) | 49 (68.1) | 17 (23.6) | 6 (8.3) |
| Combined WNV+ | 316 (80.0) | 62 (15.7) | 17 (4.3) | 164 (76.3) | 39 (18.1) | 12 (5.6) |
| Arizona WNV− | 125 (86.2) | 19 (13.1) | 1 (0.7) | 16 (84.2) | 3 (15.8) | 0 (0) |
| RBD | N/A | N/A | N/A | 1102 (83.6) | 203 (15.4) | 13 (1.0) |
All patients from Arizona and Colorado had symptoms for which WNV infection was considered as the underlying cause. WNV+, WNV seropositive; WNV−, WNV seronegative; +, wild-type CCR5 allele; Δ32, CCR5Δ32 allele; RBD, random blood donors; N/A, not applicable.