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. 2006 Oct 2;203(10):2363–2375. doi: 10.1084/jem.20060559

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Copyright © 2006, The Rockefeller University Press

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Figure 9. — LIT1-null L. amazonensis are avirulent for mice. BALB/c mice were inoculated in the left hind footpad with 10⁶ ficoll-purified metacyclic promastigotes of L. amazonensis wild type, Δlit1, Δlit1 + LIT1 episomal (pXGSAT-LIT1), or Δlit1 + LIT1 integrated (pIR1SAT-LIT1). (A) Lesion development was quantitated by weakly caliper measurements. The data corresponds to the mean ± SD of values obtained from five individual mice in each group. Parasite loads were determined in the footpad (B) or DLN (C) at 15 wk after challenge. Results shown represent parasite loads per footpad or DLN of individual mice, with geometric means and p-values between respective groups.