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. 2006 Oct 2;203(10):2305–2314. doi: 10.1084/jem.20060411

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Copyright © 2006, The Rockefeller University Press

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Figure 5. — Sensitivity to influenza virus by mice reconstituted with Blimp-1–deficient B-1 cells. Lethally irradiated muMT ⁻ mice received WT bone marrow cells and either WT (top) or CD19^Cre/+prdm1^Flox/Flox (bottom) PerC cells. 3 wk after reconstitution, anesthetized mice were intranasally infected with 4,500, 6,000, or 7,000 PFU/g body weight with A/WSN/33 influenza virus. Mice were monitored daily and weighed from days 4–14. The percentage of weight change over 14 d as compared with the initial weight on the day of infection is shown. B-2 cell reconstitution was confirmed 1 d before influenza infection, and B-1 cell reconstitution was determined on the final day of the experiment. The fraction of susceptible mice is shown.