Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2006 Oct 2;203(10):2293–2303. doi: 10.1084/jem.20060921

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2006, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 7. — Reduced capacity to process and present a lysosome-dependent analogue of α-GalCer by GSL storage APCs. Splenocytes (A, B, and E) and TNF-α–matured BMDCs (C, D, and F) from control, GM1 gangliosidosis, Sandhoff, or CD1dKO mice were pulsed for 6 h with either α-GalCer (A and C) or Gal(1→2)GalCer (B and D) and used to stimulate the DN32-D3 invariant NKT cell hybridoma (A, B, C, and D). Unpulsed splenocytes (E) and BMDCs (F) were used to stimulate the CD1d-restricted, noninvariant hybridoma TCB11 for 24 h in vitro. Supernatants were analyzed using an IL-2 ELISA. Data represent one of two independent experiments (mean ± SE; n = 2–3 mice/group).