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. 2006 Oct 2;203(10):2271–2279. doi: 10.1084/jem.20061308

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Copyright © 2006, The Rockefeller University Press

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Figure 4. — IL-22 is coexpressed with IL-17A and IL-17F in vivo. C57BL/6 mice were immunized with 100 μg OVA emulsified in CFA. 7 d after immunization, popliteal LN cells were harvested and the intracellular cytokine staining protocol was immediately performed. (A) LN cells were stained for CD4 and IL-22, IL-17A, and IL-17F. (B) IL-22 expression was analyzed in relation to IL-17A, IL-17F, IFN-γ, IL-4, and IL-10 in CD4⁺ T cells. (C) Expression of IL-22 in IL-17A⁺ and/or IL-17F⁺ populations was analyzed. (D) Expression of IL-17A and IL-17F in IL-22⁺ cells was determined. (E) LN cells were restimulated with 200 μg/ml OVA. IL-12 or IL-23 was added as indicated. IL-22 and IL-17A concentrations were examined on day 4. Data shown are representative of three independent experiments. Error bars are SD.