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. 2006 Oct 30;203(11):2441–2450. doi: 10.1084/jem.20060844

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Copyright © 2006, The Rockefeller University Press

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Figure 1. — Development of mammary carcinomas in BALB/NeuT and CD40-KO/NeuT mice. (A) Tumor growth curves showing delayed tumor onset and reduced tumor incidence (left) and tumor volume (right) in CD40-KO/NeuT (◯) versus BALB/NeuT mice (•). Tumor multiplicity is calculated as the cumulative number of incident tumors per total number of mice. Mean (± SE) of 52 mice for each group is shown. Single tumor volume is calculated as r²xR where r is the minor diameter and R the major one. The mean of cumulative tumor volumes (± SD) per mouse is shown. (B) Whole mount preparation of BALB/NeuT (top) and CD40-KO/NeuT (bottom) mammary glands at 8, 12, and 17 wk of age. The black spot in the middle is the inguinal lymph node. The dark areas surrounding the ducts correspond to hyperplastic areas. Black arrows point to solid tumor nodules. Bar, 5 mm.