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. 2006 Nov 27;203(12):2737–2747. doi: 10.1084/jem.20061577

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Copyright © 2006, The Rockefeller University Press

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Figure 2. — p31-SP–coupled cells prevent adoptive transfer of diabetes, but not peri-insulitis. Pancreata from p31-SP–tolerized and SHAM-SP control mice were stained with hematoxylin and eosin to determine clinical severity of insulitis. 100 pancreatic islets were scored for the presence of mononuclear infiltration. Representative pictures from NOD mice 7 d after receiving activated BDC2.5 T cells and either (A) p31-SP– or (B) SHAM-SP–coupled cells are shown. (C) Quantification of >100 pancreatic islets as a percentage for each histological score demonstrating that SHAM-SP–treated mice have more severe insulitis compared with p31-SP–protected mice (n = 5 mice/group; P = 0.0004).