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. 2006 Dec 25;203(13):2809–2815. doi: 10.1084/jem.20061421

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Copyright © 2006, The Rockefeller University Press

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Figure 5. — CT-1, and not IL-6, is the critical liver defense against a short period of ischemia. (A) AST and ALT levels in the serum of WT, CT-1^−/−, and IL-6^−/− mice after 10 min liver ischemia followed by 15 min of reperfusion. Values are means ± SD; 5 mice were used per treatment. (B) Representative Western blot analyses of STAT3 phosphorylation (tyr 705), STAT3 protein levels, Akt phosphorylation, and Akt protein levels in the liver of WT, CT-1^−/−, and IL-6^−/− mice under basal conditions (C) and after 10 min of liver ischemia and 15 min of reperfusion. Actin levels are shown as loading control.