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Anti-PMN antibodies decrease BAL PMNs and histamine levels proportionately in mycoplasma-infected, mast cell–deficient mice. W-sh mice were injected with control (Isotype) or PMN-directed anti–GR-1 mAb 5 d after infection with M. pulmonis (M.p.). Levels of PMN and histamine in BAL were determined 2 d after mAb injection. “Uninfected” mice were sham-infected. Data are mean ± SE; n = 3–4 animals per group; *, P < 0.05 and **, P < 0.01 compared with isotype control groups.
