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. 2006 Dec 25;203(13):2907–2917. doi: 10.1084/jem.20061232

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Copyright © 2006, The Rockefeller University Press

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Figure 9. — Antihistamines attenuate pneumonia and lung to body weight ratio in mycoplasma-infected, mast cell–deficient mice. W-sh mice were treated daily with H1-selective antihistamine (pyrilamine), H2-selective antihistamine (cimetidine), both antihistamines in combination, or saline. Lungs harvested 10 d after infection and 7 d after starting antihistamine treatment were weighed and subjected to histopathological scoring for pneumonia (maximal possible score is 26). The top panel shows pneumonia grades in each group. The bottom panel shows ratio of lung weight (mg) to body weight (g). Data are mean ± SE; n = 5–8 animals per group; *, P < 0.05 and ***, P < 0.001 compared with saline control.

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