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. 2006 Feb 20;203(2):425–435. doi: 10.1084/jem.20052148

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Copyright © 2006, The Rockefeller University Press

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Figure 5. — PAR₂ deficiency diminishes CNS inflammatory cell infiltration, demyelination, and axonal loss during EAE induction. (A) WT EAE animals showed higher number of Iba-1⁺ cells (first column), associated with worsened demyelination (second and third columns), and a higher number of CD3-immunopositive lymphocytes (fourth column) compared with littermate KO EAE or intact animals. Silver staining displayed more axonal injury/loss in WT EAE animals (fifth column) compared with KO EAE or intact animals. (B) Quantification of macrophage/microglial, (C) myelin, (D) lymphocyte reactivity, and (E) axonal counts showed significantly higher inflammatory cell infiltration together with more severe demyelination and axonal loss in WT EAE animals. All quantitative analyses represented the results of four animals per group. Tukey-Kramer Multiple Comparisons test; *, P < 0.05; **, P < 0.01; ***, P < 0.001. Error bars represent standard errors.