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. 2006 Feb 20;203(2):437–447. doi: 10.1084/jem.20051775

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Copyright © 2006, The Rockefeller University Press

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Figure 2. — Microchimerism in transplant recipients of liver grafts from untreated B6 and [bm8→B6] radiation bone marrow chimeras. (A) bm8 (CD45.2) recipients of untreated B6.SJL (CD45.1) livers were killed 4 wk after liver transplantation. The frequency and phenotype of donor-derived passenger leukocytes in spleens and peripheral lymph nodes was assessed by eight-color flow cytometry based on the congenic marker CD45.1. (B) Microchimerism in recipients of livers from radiation bone marrow chimeras, in which the bone marrow–derived cells were replaced by bone marrow of the recipient mouse strain (bm8) 4 wk before liver transplantation. Data are representative of two independent experiments with three mice per group. Bottom: average percentage (±SEM) of donor-derived passenger leukocytes as a fraction of the total number of donor-derived CD45.1⁺ cells (six animals per group). The radiation reduced microchimerism by 90% and abolished the transfer of professional APCs (dendritic cells and B cells).