Table II.

Classification of genes whose expression level was potentiated by an IP agonist

Group	Unigene code	Gene symbol	Gene profiles	Vehicle vs. Il-1β Log2(fold)	Il-1β vs. Il-1β+Indo Log2(fold)	Il-1β+Indo vs. Il-1β+Indo+IP agonist Log2(fold)
Inflammation	Mm.35814	Il11	Interleukin 11	4.1	−3	2.3
	Mm.35692	Il1rl1	Interleukin 1 receptor–like 1	2.3	−1	0.3
	Mm.896	Il1r1	Interleukin 1 receptor, type I	0.7	−0.7	0.9
	Mm.14595	Csf2rb1	Colony stimulating factor 2     receptor, β1, low-affinity	1.5	−0.6	1.3
	Mm.4186	Pla2g4a	Phospholipase A2, group IVA(cPLA2)     (cytosolic, calcium-dependent)	1.1	−0.6	0.5
	Mm.1401	Cxcr4	Chemokine (C-X-C motif) receptor 4	0.7	−1.1	1.3
	Mm.157750	Cxcl7	Chemokine (C-X-C motif) ligand 7	1.1	−0.8	1.2
Proliferation	Mm.31540	Vegfa	VEGF-A	1.8	−0.9	0.9
	Mm.57094	Fgf2	FGF-2	2.4	−2.7	2
	Mm.57177	Fgf7	FGF-7	0.9	−0.6	0.5
	Mm.20424	Fgf18	FGF-18	2.6	−4	2
	Mm.3879	Hif1a	Hypoxia inducible factor 1,     α subunit	1	−0.8	0.7
	Mm.27969	Uap1	UDP-N-acetylglucosamine     pyrophosphorylase 1	2.7	−3	3.2
	Mm.2580	Sdc1	Syndecan 1	0.8	−0.6	1.8
	Mm.4575	Cspg2	Chondroitin sulfate proteoglycan 2	0.8	−1	1.5
	Mm.2542	Has1	Hyaluronan synthase1	2.2	−2.7	3.3
	Mm.5148	Has2	Hyaluronan synthase 2	1.3	−1.6	1.8
Bone and tissue  destruction	Mm.6426	Tnfsf11 (RANKL)	Tumor necrosis factor (ligand)     superfamily, member 11	4.2	−3.1	2.9
	Mm.1421	Adamts1	A disintegrin-like and metalloprotease     (reprolysin type) with     thrombospondin type 1 motif, 1	2.4	−1.5	0.7
	Mm.39718	Adamts5	A disintegrin-like and metalloprotease     (reprolysin type) with     thrombospondin type 1 motif, 5	1.1	−0.9	0.3
	Mm.15969	Adam8	A disintegrin and metalloprotease     domain 8	0.6	−0.6	1.2
	Mm.44170	Vdr	Vitamin D receptor	1.5	−3.2	3.4

22 genes are chosen from cluster 4 of Table I and are classified based on their functions. The change in expression level is indicated as a logarithm of the fold-change. Indo, indomethacin.