Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2006 Mar 20;203(3):493–495. doi: 10.1084/jem.20060217

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2006, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 1. — Physiological coagulation. The extrinsic pathway is initiated by the binding of FVII to TF which results in the autoactivation of FVII (FVII_a). The activation of this pathway ultimately leads to the formation of thrombin, which feeds back to activate FXI on the surface of platelets. FXI_a then triggers the intrinsic pathway generating more thrombin and accelerating fibrin formation.