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. 2006 Mar 20;203(3):493–495. doi: 10.1084/jem.20060217

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Copyright © 2006, The Rockefeller University Press

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Figure 2. — Pathological thrombosis FXII is activated by exposure to negatively charged molecules to factor XIIa (FXII_a). FXII_a then cleaves FXI to FXI_a, thus triggering the intrinsic pathway. Factor XII_a also hydrolyzes FVII to FVII_a, which combines with TF on the surface of activated monocytes or vascular cells to initiate the extrinsic system. Both coagulation pathways are required for pathological thrombosis as occurs during stroke and disseminated intravascular coagulation.