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. 2006 Mar 20;203(3):553–561. doi: 10.1084/jem.20052438

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Copyright © 2006, The Rockefeller University Press

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Figure 2. — MyD88 deficiency protected against generation of IgG2a and 2b polyreactive autoantibodies. IgG2a_b and 2b analysis of autoantibodies in the serum of 5-mo-old wt.B6 (n = 4), FcγRIIB^−/−MyD88^+/−.B6 (n = 8), and FcγRIIB^−/−MyD88^−/−.B6 (n = 6) mice. Shown are antiglomerular basement membrane (GBM) (A), anticardiolipin (Cardiol.) (B), and anti-DNA (C) titers as determined by ELISA. Polyreactivity was analyzed by preabsorbing the samples on the indicated ELISA plates; G: GBM; C: cardiolipin; G,C: GBM + cardiolipin. IgG1 and IgG3 titers were not significantly elevated over baseline (not depicted). Horizontal bars represent the average.