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. 2006 Mar 20;203(3):767–776. doi: 10.1084/jem.20051732

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Copyright © 2006, The Rockefeller University Press

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Figure 4. — Recombinant ADAMTS13 inhibits platelet strings in Adamts13^−/− mice. Rhodamine 6G was used to label endogenous platelets and leukocytes. Histamine was administered i.p. 15 min before surgery and three mesenteric venules of ∼200–300 μm in diameter were visualized per mouse. (A) No platelet strings are seen in Adamts13 ^+/+ mice (n = 5). (B) Platelet strings (indicated by arrows) are seen in the Adamts13 ^−/− mice. Platelet strings anchor up to 1 min on the endothelium (n = 5). (C) The platelet strings could form platelet aggregates in Adamts13 ^−/− mice as indicated by arrow. (D) Infusion of r-hu ADAMTS13 protein inhibits the platelet strings in Adamts13 ^−/− mice (n = 4).