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. 2006 Mar 20;203(3):541–552. doi: 10.1084/jem.20050407

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Copyright © 2006, The Rockefeller University Press

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Figure 2. — Inflammatory status of host determines pathogenicity and phenotype of MLN lymphocytes. Flow cytometry was performed on MLN lymphocyte populations in SAMP (n = 3), AKR (n = 3), AKR BM → SAMP (n = 7), and SAMP BM → AKR (n = 6) mice. (A) Representative T cell–gated (CD4⁺CD8⁺) dotplots of CD4 (y) versus CD69 (x) expression, with percentages of CD4⁺ T cells that are CD69⁺. (B) Representative dotplots of B220 (x) versus IgA (y) expression, with averages of IgA⁺B220^hi mature B cells and IgA⁺B220^int plasmablasts as a percentage of all lymphocytes. Results are expressed as mean ± SEM. *Indicates significantly increased (P < 0.05) compared with AKR or SAMP BM → AKR mice. Lymphocyte subsets that were significantly increased in SAMP (x) versus AKR (y) mice included the percentage of IgA⁺ cells (♦) and the percentage of CD4⁺ T cells that were α_E ⁺ (▵), β₇ ^hi (□), CD25⁺ (•), CD44^hi (▴), CD69⁺ (⋄), and l-selectin^lo (▪) (C, left). Similar trends were seen in a plot of SAMP BM → AKR (y) versus AKR BM → SAMP (x) subsets (C, right). The slopes of the best-fit lines through the points in the two plots were not significantly different.