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. 2006 Mar 20;203(3):541–552. doi: 10.1084/jem.20050407

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Copyright © 2006, The Rockefeller University Press

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Figure 6. — Early, preinflammatory alterations in small intestinal barrier function persist in the absence of the enteric flora. (A) Small intestinal paracellular permeability in GF SAMP mice was similar to permeability in SAMP mice raised under SPF conditions, and significantly increased compared with SPF-AKR permeability n ≥ 4 per group; *P < 0.05 versus age-matched AKR. (B) 3-wk-old GF SAMP mice displayed no histological signs of ileal inflammation and possessed normal intestinal architecture.