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Homing of CD4+ T cells to the terminal ileum is impaired in PSGL-1–deficient mice. Chromium 51–labeled L-selectin+ CD4 T cells were injected into PSGL-1–sufficient (+/+) and –deficient (−/−) TNFΔARE mice as per Materials and methods. Radioactivity was determined in the aforementioned organs 72 h after cell transfer. Error bars show the mean ± SEM from three mice/experimental group. *, P < 0.05.
