Figure 2.

Administration of rIL-25 induces rapid worm expulsion that is independent of T and B cells, but dependent on type 2 cytokine production. Cohorts of mice (n = 3–5 per group) were infected with N. brasiliensis in the presence or absence of rIL-25 and killed on days 5 or 10 to obtain intestinal worm counts. Data are presented as means plus standard error and are representative of two to three experiments. ND, not detected. (A) Wild-type and il25 ^−/− mice. (B) Wild-type and rag1 ^−/− mice. (C) Wild-type and il4 ^−/− il5 ^−/− il9 ^−/− il13 ^−/− mice.