Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2006 Apr 17;203(4):1117–1127. doi: 10.1084/jem.20052321

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2006, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 1. — Probucol and probucol dithiobisphenol, but not probucol bisphenol, inhibit atherosclerosis in Apoe^−/− mice. (A) Lesion area in animals treated with probucol (P, ♦), probucol dithiobisphenol (DTBP, ▪), or probucol bisphenol (BP, ▴) compared with control (Ctrl, ○). n = 10 for each site, each using two, six, and three serial sections for arch, thoracic (TA), and abdominal aorta (AA), respectively. (B) Representative cross sections of abdominal aorta from control and the three treatment groups stained for macrophages indicating respective lesion size. Bar, 25 μm. (C) Plasma cholesterol, n = 10. (D) FPLC chromatograms of lipoproteins from pooled plasma (n = 10) of control, probucol, probucol dithiobisphenol, and probucol bisphenol animals. (E) Neutral lipids (NL, comprised of cholesterylesters and triglycerides) and (F) their hydroperoxides (LOOH) standardized to NL. n = 3 pools of five aortas per pool. (G) Average lesion area covered by Mac-3⁺ cells (i.e., macrophages) and (H) PCNA⁺ (i.e., proliferating) cells in the arch, thoracic, and abdominal aorta as compared with corresponding control. n = 3 for each site (three serial sections/site). *, P < 0.05; **, P < 0.01; ***, P < 0.001 compared with control.