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. 2006 Apr 17;203(4):1117–1127. doi: 10.1084/jem.20052321

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Copyright © 2006, The Rockefeller University Press

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Figure 5. — Vitamin E fails to inhibit intimal hyperplasia and does not promote reendothelialization or induce HO-1. (A) HO-1 mRNA assessed by real-time RT-PCR in rabbit aortic smooth muscle cells cultured for 24 h in the presence of vehicle (control), 50 μM probucol, or 50 μM α-tocopherol (VE). (B) Reendothelialization assessed by Evans blue staining for the three groups of rabbits shown in A 3 wk after injury. (C) Intima-to-media ratio of vessels from control rabbits and animals treated with probucol or α-tocopheryl acetate (VE) (n = 6 per group) 3 wk after aortic balloon injury (five serial sections per aortic segment, 100 μm apart). Results show mean ± SEM of a triplicate experiment performed twice with similar results obtained in both experiments. Symbols and abbreviations are as described in the legend to Fig. 1.