Table III.

Morphometry of carotid artery after balloon injury of lean and obese Zucker rats

	Lean (n = 9)	Obese (n = 9)	Obese + probucol (n = 9)
Intimal area (mm2)	0.01 ± 0.0	0.12 ± 0.01a	0.05 ± 0.01b
Medial area (mm2)	0.13 ± 0.01	0.16 ± 0.0a	0.15 ± 0.01
Intima-to-media ratio	0.08 ± 0.03	0.74 ± 0.05a	0.28 ± 0.06b
Reendothelialization (%)	100 ± 0	42 ± 8a	80 ± 13b
Total intimal cells (number     per high powered field)	ND	237 ± 13	78 ± 28b
PCNA+-cells in intima	ND	50 ± 17	11 ± 7b

Probucol (1%, wt/wt) was administered for 4 wk, with carotid balloon injury performed after 2 wk and carotid artery morphometry, reendothelialization, and intimal cell proliferation assessed at the end of the 4-wk intervention as described in Materials and methods. Total and PCNA⁺ cells were assessed as the number of cells per high power field (average of three fields). Values are mean ± SEM. ND, not detected.

^aP < 0.05 versus lean.

^bP < 0.05 versus obese.