Table I.
Identification of FOXO3a-inducible genes by Affy-array (up-regulated: ↑; down-regulated: ↓)
| Genes | Function | Validated (QRT-PCR) |
|---|---|---|
| Bcl-2 binding component 3 (puma) |
BH-3 only family member, apoptotic factor |
+ (↑) |
| Cyclin-dependent kinase inhibitor 1B(p27) |
cell cycle regulator: G1 checkpoint |
+ (↑) |
| DnaJ (Hsp40) homologue, subfamily C, member 12 |
molecular chaperones | + (↑) |
| Insulin-like growth factor I receptor, (Igf1r) |
insulin signaling | + (↑) |
| Sestrin 1 | modulator of peroxide signaling and antioxidant defense |
+ (↑) |
| Vascular endothelial growth factor A (Vegfa) |
vasculogenesis and angiogenesis |
+ (↓) |
| Cyclin D2 | cell cycle regulator: G1/S checkpoint |
+ (↓) |
| Eph receptor A2 (Epha2) | vasculogenesis and angiogenesis |
+ (↓) |