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. 2006 Jul 10;203(7):1805–1815. doi: 10.1084/jem.20052545

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Copyright © 2006, The Rockefeller University Press

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Figure 5. — BMDCs from IL-12p40–deficient mice fail to migrate from the lung when activated by Mtb. BMDCs from B6 and gene-deficient mice were exposed to irradiated Mtb for 3 h, washed, labeled with TAMRA orange, and delivered intratracheally to B6 mice. The frequency (a) and number (b) of CD11c⁺/TAMRA-labeled cells within the DLN was then determined over time using flow cytometry. The frequency and number of CD11c⁺/TAMRA-labeled cells within the lung were also determined on day 2 (filled bars) and day 4 (striped bars) (c). Data points represent the mean for each group (n = 3–4). One experiment representative of two total experiments is shown. p-values were determined by the Student's t test.