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. 2006 Jul 10;203(7):1685–1691. doi: 10.1084/jem.20060285

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Copyright © 2006, The Rockefeller University Press

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Figure 2. — The induction of EAE and autoantigen-specific ThIL-17 cells is dependent on functional IL-1RI. C57BL/6 or IL-1RI^−/− mice were injected with 150 μg MOG in 200 μl CFA and 500 ng PT followed 2 d later with a second dose of PT. Mice were observed for clinical symptoms of EAE daily for 48 d. A separate group of mice were killed on d 21, and spleen cells were restimulated with MOG peptide. After 3 d, supernatants were collected and cytokine concentrations were determined by ELISA. Cell proliferation was determined on day 4 of culture by [³H]thymidine incorporation. (A) Disease scores (n = 15) ± SD. (B) Antigen-specific cytokine production and proliferation. C57BL/6 versus IL-1RI^−/−: *, P < 0.05; **, P < 0.01; ***, P < 0.001. (C) IL-1RI^−/− mice (n = 7) were injected with MOG in CFA followed by PT as described above or with MOG-specific T cells (9 × 10⁶ cells/mouse) generated from the spleens of C57BL/6 mice with EAE. Disease scores (n = 5) ± SD.