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. 2006 Aug 7;203(8):1915–1925. doi: 10.1084/jem.20052085

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Copyright © 2006, The Rockefeller University Press

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Figure 6. — Effects of PI3 kinase inhibitor on macrophage phagocytosis and NADPH oxidase activity elicited by IgG-opsonized latex beads. Murine PEMs were incubated with varying concentrations of wortmannin or LY294002 for 30 min at 37°C or with DMSO vehicle (control) before adding IgG-opsonized latex beads (3.3 μm). Data is the mean ± SD (n ≥ 3 experiments). (A) The percentage of macrophages with internalized beads (black bars) and the phagocytic index (white bars; data normalized as the percentage of the phagocytic index for vehicle-treated control macrophages, which was ∼400–600) are shown. (B) NADPH oxidase activity during phagocytosis of IgG beads, as measured by lucigenin-dependent chemiluminescence integrated over 60 min. Data is the mean ± SD (n ≥ 3 experiments). The background signal from gp91^phox-null PEM samples run in parallel was 90.0 ± 27.8 and has been subtracted from the wild-type PEM signal.