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. 2006 Aug 7;203(8):1963–1975. doi: 10.1084/jem.20060039

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Copyright © 2006, The Rockefeller University Press

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Figure 8. — Interactions between Thy1.1⁺D^bGP_33–41-specific T cells and MHC II⁺ APCs in the CNS of immunotherapy recipients. Three-color confocal microscopy was used to demonstrate immunological synapse formation between GFP⁺D^bGP_33–41-specific T cells (blue) and MHC II⁺ APCs (red) in the meninges, choroid plexus, and brain parenchyma of immunotherapy recipients. Immunological synapses were indicated by the polarization of the adhesion molecule LFA-1 (green) between the CTL and APC (25). Asterisks denote the engaged APC, and arrows denote the contact point between the two cells. LFA-1 is expressed on both CTLs and APCs, but note that all of the CTL-associated LFA-1 is focused toward a contact point at the CTL–APC interface. Two representative examples are shown for day 8 immunotherapy recipients (n = 3).