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. 2006 Sep 4;203(9):2109–2119. doi: 10.1084/jem.20052267

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Copyright © 2006, The Rockefeller University Press

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Figure 1. — CO protects against and reverses MCT-induced experimental PAH in rats. (A) Kinetics demonstrating increasing mPAP at 2, 4, and 6 wk after a single s.c. injection of MCT on day 0. Results represent means ± SD of six to eight rats/group. *, P < 0.02 versus untreated rats. (B) Representative histological specimen of pulmonary arteriole 6 wk after MCT treatment with and without exposure to 250 ppm CO on days 29–42. Note that MCT increases medial expansion without thrombosis, whereas those animals treated with CO showed considerably reduced vascular hyperplasia. Images are representative of six to eight sections/lung from four to six rats. (C) CO reverses MCT-induced pulmonary arteriolar thickening in rats treated with CO on days 29–42 after MCT. Data are presented as percent wall thickness calculated as the area bounded by the internal and external laminae (see Materials and methods). Results represent means ± SD of 10 vessels from the lungs of five rats/group. *, P < 0.02 versus CO and CO/MCT. (D) In the genetically predisposed FHH rats, a significant reduction in mean RV pressures (which is reflective of mPAP) was observed in those animals treated with CO. Results represent means ± SD of four to six rats/group. *, P < 0.01 versus air- and CO-treated rats.