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. 2006 Sep 4;203(9):2145–2155. doi: 10.1084/jem.20060651

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Copyright © 2006, The Rockefeller University Press

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Figure 2. — Induction of CTL response and virus elimination in CD27^−/− mice. (A) CTL activity (⁵¹Cr release assay) 8 d after LCMV-WE infection. Closed symbols, gp33-pulsed target cells; open symbols, unpulsed target cells. (B and C) The absolute number of D^b-gp33–specific CD8⁺ T cells measured by tetramer staining (B) and virus titer (C) were assessed in the spleen after LCMV-WE infection. (D) Cytokine production of purified P14 and P14 × CD27^−/− T cells 8 d after adoptive transfer to BL/6 recipients and LCMV-WE infection. Data are expressed as the mean ± SEM (error bars) of n = 3–4 animals and are representative of one of two individual experiments. ns, P ≥ 0.05.