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. 2006 Sep 4;203(9):2191–2200. doi: 10.1084/jem.20060077

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Copyright © 2006, The Rockefeller University Press

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Figure 2. — rt-PA elicits NE release in guinea pig heart synaptosomes and neuroblastoma cells: potentiation by fibrinogen. (A and C) Concentration response curves for the NE-releasing effects of rt-PA in guinea pig heart synaptosomes (endogenous NE) and human SH-SY5Y neuroblastoma cells ([³H]NE). Points are means (± SE [error bars]; n = 8–14) of percent increases in NE release above baseline. (B and D) Coincubation of rt-PA with 200 μg/ml of the fibrinogen digest CNBr-F significantly potentiates the NE-releasing effect of 1 (B) and 0.3 μg/ml (D) rt-PA in guinea pig heart synaptosomes and SH-SY5Y neuroblastoma cells. Bars are means (± SE; n = 4–8) of increases in NE release above baseline. *, P < 0.05 versus baseline; **, P < 0.01 versus baseline.