Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2006 Sep 4;203(9):2191–2200. doi: 10.1084/jem.20060077

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2006, The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 7. — t-PA promotes NE release and associated arrhythmias in myocardial ischemia/reperfusion. (A) Coronary NE overflow before ischemia (basal) and during 10-min reperfusion in hearts isolated from t-PA^−/−and PAI-1^−/− mice and their WT controls. Global stop-flow ischemia was applied for 30 min after an initial stabilization period of 30 min. NE overflow was individually adjusted for coronary flow and heart weight. Points are means (± SE [error bars]; n = 9–11). Asterisks indicate significant differences from 5-min reperfusion levels in t-PA^−/− hearts (*, P < 0.05). (B) Analysis of ventricular arrhythmias during reperfusion of the same hearts as in A. The incidence of high-grade ventricular arrhythmias (i.e., ventricular tachycardia [VT] and ventricular fibrillation [VF]) is expressed as percentages of the total number of hearts used in each of the three groups (± SE). The duration of VT and VF represents the cumulative duration of arrhythmia during the 30-min reperfusion. The occurrence of premature ventricular contractions (PVCs) is expressed as the total number (n) of PVCs counted during the 30-min reperfusion. Bars are means (± SE; n = 9–11). Asterisks indicate significant differences from WT and PAI-1^−/− hearts (incidence of VT/VF) and from WT and t-PA^−/− hearts (number of PVCs).