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. 2007 Jan 22;204(1):191–201. doi: 10.1084/jem.20061631

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Copyright © 2007, The Rockefeller University Press

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Figure 6. — Thy1.1⁺ BDC T reg cells do not persist after successful treatment of diabetes. (A and B) Diabetic NOD Thy1.2 mice successfully treated with 10⁶ Thy1.1 BDC T reg cells were harvested 50 d after T reg cell injection (10 d after insulin pellets were removed). The percentage of lymphocytes in the pancreatic lymph node (A) or the pancreas (B) that are either CD4⁺ Thy1.1⁺ or CD4⁺ Thy1.1⁻ are shown. (C and D) 12-wk-old nondiabetic Thy1.2 NOD mice were injected with nothing (left) or 10⁶ CD62L⁻ (middle) or CD62L⁺ (right) T reg cells from BDC Thy1.1 mice. The percentages of lymphocytes 7 d later in the pancreatic lymph node (C) or the pancreas (D) that are either CD4⁺ Thy1.1⁺ or CD4⁺ Thy1.1⁻ are shown. (E and F) Pancreas from diabetic NOD Thy1.2 mice successfully treated with Thy1.1 BDC T reg cells (E) or pancreatic lymph node of prediabetic NOD Thy1.1 mice (F) were stained for CD4 (green), Foxp3 (red), and Thy1.1 (blue).