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. 2007 Jan 22;204(1):153–160. doi: 10.1084/jem.20061918

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Copyright © 2007, The Rockefeller University Press

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Figure 4. — Extent of allelic inclusion in the edited B-cell compartment. (A) Igκ^αHEL/h splenic B cells were isolated by single-cell sorting, and 387 Igκ transcripts were amplified by RT-PCR and analyzed by sequencing (top). From this analysis, six populations were characterized as shown (bottom). The VκαHEL prerecombined light chain is depicted by a yellow rectangle, and secondary recombination events at the mCκ and hCκ alleles are depicted with red or blue rectangles, respectively. OOF rearrangements are depicted by rectangles with a slash, and use of the lambda locus is represented with a green rectangle. (B) Analysis of in-frame and OOF status of Igκ transcripts in Igκ^αHEL/h or Igκ^m/h B cells. Igκ^αHEL/h cells were the same as those shown in A.