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. 2007 Oct 1;204(10):2407–2422. doi: 10.1084/jem.20070628

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Copyright © 2007, The Rockefeller University Press

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Figure 2. — IRAK-4 deficiency. (A) Schematic representation of IRAK4 with all identified mutations. The gene is composed of 12 exons, with exon 1 and a part of exon 12 noncoding. The N-terminal death domain (DD) and C-terminal kinase domain (KD) are shown in light gray. (B) RT-PCR of the full-length IRAK4 and GAPDH genes in B-EBVs from a healthy control (C) and nine IRAK-4–deficient patients. (C) IRAK-4 and GAPDH protein levels in B-EBVs from a healthy control and nine IRAK-4–deficient patients, as shown by Western blotting. White lines indicate that intervening lanes have been spliced out.