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Impaired cellular responses to TIR agonists in IRAK-4–deficient cell lines. (A) TNF-α production by B-EBVs from a healthy control (C) and seven IRAK-4–deficient patients 24 h after stimulation with various TLR agonists and PMA/ionomycin. (B) IL-6 production by SV40-fibroblasts from a healthy control and eight IRAK-4–deficient patients after 24 h of stimulation with IL-1β, TNF-α, poly(I:C), and PMA/ionomycin. Mean values and SDs are shown for triplicates of a single experiment.
