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. 2007 Oct 1;204(10):2439–2448. doi: 10.1084/jem.20070404

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Copyright © 2007, The Rockefeller University Press

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Figure 1. — APC reduces the mortality of LPS-induced endotoxemia. 7-d survival of mice (n = 20 per group) infused with 10 μg APC (○), 2 μg APC (Δ), PBS (•), or 10 μg S360A-APC (□; n = 10 per group) over a 20-min period before challenge with an LD₅₀ (A) or LD₉₀ (B) of LPS. The statistical significance of mortality and survival time was determined by the Kaplan-Meyer log-rank test.