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. 2007 Oct 1;204(10):2439–2448. doi: 10.1084/jem.20070404

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Copyright © 2007, The Rockefeller University Press

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Figure 7. — 5A-APC reduces mortality in bacterial sepsis. (A) Survival of mice (n = 10 per group) given either a 10-μg (□) or 2-μg (▪) i.v. bolus of 5A-APC or PBS (•, control), followed immediately by i.p. infection with 10⁸ S. aureus. (B) Survival of mice (n = 20 per group) given a 2-μg i.v. bolus of either 5A-APC (▪) or PBS (•, control) 3 and 10 h after i.p. infection with 10⁸ S. aureus. (C) Survival of mice (n = 20 per group) given a 2-μg i.v. bolus of either 5A-APC (▪) or PBS (•, control) at 3 and 10 h after i.p. infection with 2.5 × 10⁸ E. coli (O55:B5). (D) Survival of mice (n = 22 per group) after CASP. Mice were given a 2-μg i.v. bolus of either 5A-APC (▪) or S360A-APC (•) at 3 and 10 h after CASP. The statistical significance of mortality reduction by APC treatment was determined by the Kaplan-Meyer log-rank test.