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. 2007 Oct 29;204(11):2545–2552. doi: 10.1084/jem.20071401

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Copyright © 2007, The Rockefeller University Press

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Figure 3. — LC development requires the direct action of TGFβ, and escaped LCs repopulate the epidermis in clusters. (A) FACS of live gated epidermal cells from Langerin-Cre TGFβRII^f/f (right) and littermate controls (left) stained for TGFβRII (top) or isotype control (bottom). (B) Each symbol represents the ratio of the percentage of epidermal LCs in an individual Langerin-Cre TGFβRII^f/f mouse compared with a sex- and age-matched control. The percentage of LCs in Langerin-Cre TGFβRII^f/f increases with age. P < 0.05. (C) Immunofluorescence of epidermal whole mounts from Langerin-Cre TGFβRII^f/f at the indicated age or WT mice stained for MHC-II (green). The majority of fields lack LCs. Representative fields that contain LCs are shown. Bars: (Day 22) 37.5 μm; (Days 60 and 89 and WT) 75 μm.