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. 2007 Oct 29;204(11):2545–2552. doi: 10.1084/jem.20071401

Figure 4.

Figure 4.

Steady-state LC development requires LC-derived TGFβ1. (A) A representative FACS analysis of live gated epidermal cells from 4-wk-old Langerin-Cre TGFβ1f/f (right) compared with control mice (left). (B) Each symbol represents the percentage of LCs in an individual Langerin-Cre TGFβf/f mouse or control. (C) Immunofluorescence of epidermal whole mounts from Langerin-Cre TGFβ1f/f or WT mice stained for MHC-II (green) and Langerin (red). As with the Langerin-Cre TGFβRIIf/f, most fields lack LCs, and a representative field containing LCs is shown. Bar, 75 μm.