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. 2007 Oct 29;204(11):2545–2552. doi: 10.1084/jem.20071401

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Copyright © 2007, The Rockefeller University Press

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Figure 5. — LC repopulation in chimeric mice requires LC-derived TGFβ1. BM chimeras were generated by transferring BM from either Langerin-Cre⁺ TGFβ1^f/f mice (A and B, bottom rows) or littermate Langerin-Cre⁻ TGFβ1^f/f controls (A and B, top rows) into irradiated congenic B6.CD45.1 recipients. Recipients were either exposed to 450 mJ of UVC 1 d after transplant (A) or not irradiated (B). After 8 wk, immunofluorescence of epidermal ear whole mounts were stained for CD45.2 (green) and Langerin (red) to determine the presence of donor LCs. Representative data from three independent experiments are shown. Bar, 75 μm.